Chronic Neuropathic Pain Treatment Options in the Head and Neck:

Effective Management Strategies including drugs and stem cells

Chronic neuropathic pain can be managed effectively with certain medications or advanced treatment options including stem cells. Medications include antidepressants like amitriptyline, duloxetine, and venlafaxine that work by altering neurotransmitters in the brain and spinal cord to alleviate pain. Stem cells work by repairing or regenerating damaged nerve fibers. It is the treatment of last resort.

Our website provides a range of potential treatment options for chronic neuropathic pain, including stem cell therapy, physical therapy, medication management, and interventional procedures. These treatments aim to provide relief from chronic neuropathic pain and improve overall quality of life.

Types of diseases causing head and neck pain:

There are many diseases causing head and neck pain including:

  • Trigeminal neuralgia
  • TMJ dysfunction
  • Dental pain/toothache/jaw pain
  • Migraine
  • Headache
  • TMJ osteoarthritis/Costens syndrome
  • Dry mouth
  • Dry eyes
  • Glossopharyngeal neuralgia
  • Eagles syndrome

Medications for Neuropathic Pain: Antidepressants, Anticonvulsants, Opioids and Analgesics

When it comes to managing chronic neuropathic pain, different classes of medications offer unique ways to alleviate discomfort. Antidepressants like amitriptyline, duloxetine, and venlafaxine significantly contribute to pain relief by influencing neurotransmitters in the brain and spinal cord. This alteration not only helps in lifting mood but also serves as an effective means to mitigate nerve pain.

Amitriptyline, for instance, is an antidepressant that can effectively quell neuropathic pain. Its ability to inhibit the reuptake of both serotonin and norepinephrine is vital in reducing the perception of pain and potentially altering the way pain signals are processed in the brain and spinal cord. Duloxetine targets both serotonin and norepinephrine reuptake inhibition, thereby modulating nerve signaling related to neuropathic pain. Venlafaxine acts on similar neurotransmitters, providing relief from both physical discomfort and underlying associated conditions.

Moving on to anticonvulsants, these medications like gabapentin and pregabalin play a crucial role in soothing nerve pain by stabilizing electrical activity in the nervous system. This stabilization is essential in lowering the abnormal firing of nerves that leads to neuropathic pain.

Gabapentin is proven to be effective in controlling neuropathic pain by regulating neuronal hyperexcitability without affecting normal synaptic transmission or blocking nerve conduction. Pregabalin acts similarly by binding to certain calcium channels within neurons, thereby preventing excessive neurotransmitter release involved in the transmission of pain signals. These mechanisms work together effectively presenting a robust approach in curbing neuropathic discomfort.

In severe cases where neuropathic pain poses significant challenges, opioids such as tramadol or tapentadol, along with analgesics like codeine may be considered under strict medical supervision. These medications hold considerable potency in addressing severe levels of neuropathic pain; however, their usage demands caution due to the potential for addiction and other undesirable side effects.

Tramadol functions as a centrally acting analgesic that impacts both opioid receptors and inhibits serotonin and norepinephrine reuptake. It has been found to be beneficial in alleviating moderate to severe neuropathic pain while limiting the possibility of respiratory depression often linked with traditional opioid use. Similarly, tapentadol presents a dual mode of action through its affinity for opioid receptors and inhibition of norepinephrine reuptake. It's important to remember that balanced administration under the guidance of a healthcare professional is paramount when considering these potent medications due to their potential for dependence and adverse effects.

The right medication plays a pivotal role in managing neuropathic pain; however, it's not the only weapon in our arsenal. Expanding our understanding of treatment options will now lead us towards exploring non-pharmacological approaches for effectively managing chronic neuropathic discomfort.

Stem Cells

There are numerous reports of stem cells being effective in managing the conditions above. In general, mesenchymal adipose stem cells are used to repair and regenerate damaged nerves. This is advanced treatment undertaken when all other measures have failed.

Physical Therapy, Exercise and Lifestyle Adjustments for Neuropathic Pain

When it comes to neuropathic pain, every aspect of life can play a role in managing symptoms. Let's start with physical therapy. These exercises are designed to improve not only your strength, but also your flexibility and range of motion.

Imagine that by doing certain exercises, you're actually helping your body work better and reducing pain along the way. You might work with a physical therapist who will create a program just right for you. They consider what hurts and what doesn't so you can build strength without making things worse.


Low-impact aerobic exercises and strength training help release endorphins, which act as natural painkillers. By staying active, you're not letting the pain control what you do. But remember, it has to be the right kind of exercise - nothing too tough that it could make things worse.

Lifestyle Adjustments

Making changes to everyday habits can significantly impact how you feel. It’s pretty amazing how little changes to our daily routines can have such a big impact.

  • Maintaining a healthy weight: When you carry less weight around, there's less strain on your muscles and bones, making it easier for them to work as they should.
  • Managing stress: Finding ways to deal with stress can be really good for your overall health. When you're less stressed, it can sometimes make your pain feel not as bad too.
  • Ensuring adequate sleep: A good night's sleep makes everything feel more tolerable, doesn't it? It works that way for your neuropathic pain too.

Combining these approaches with any ongoing treatments or medications suggested by your doctor gives you all the tools needed to manage neuropathic pain effectively.

Incorporating different forms of intervention can provide relief when coping with neuropathic pain. Now, let's explore how interventional treatments like injections and stimulation can offer further support and respite from persistent discomfort.

Interventional Treatments: Injections and Stimulation

For many individuals coping with chronic neuropathic pain, daily life can feel like an unceasing battle. This is where interventional treatments come into play, offering a glimmer of hope for those seeking respite from constant discomfort. Stem cells are harvested from your own adipose tissue and injected or infused to treat the pain.

Nerve Blocks

When it comes to nerve blocks, imagine it as a targeted rescue mission for the affected nerves. This procedure involves injecting anesthetics, stem cells or anti-inflammatory medications directly onto the nerves causing pain. The aim is to temporarily block the pain signals, providing much-needed relief. This could be compared to hitting the pause button on a relentless cycle of discomfort and allowing the body to take a breather from the persistent agony.

The effectiveness of nerve blocks can vary from person to person. Some may experience immediate and profound relief, while others may find that their symptoms gradually improve over time following multiple injections. It's important to note that this treatment typically provides temporary relief, yet for many, even brief periods of respite can significantly impact their overall quality of life.

Spinal Cord Stimulation

Now, picture spinal cord stimulation as a carefully orchestrated symphony designed to interrupt the relentless pain signals traveling along your spinal cord. Through a surgical procedure, electrodes are implanted near the spinal cord and connected to a small device that generates electrical pulses. These pulses essentially work to modify and mask the pain signals before they reach your brain, providing relief for individuals grappling with severe neuropathic pain that has proven resistant to other treatments.

It's essential to understand that spinal cord stimulation isn't a one-size-fits-all solution. Success rates can vary widely depending on individual response and pain profiles. Those who experience favorable results often report a significant reduction in pain intensity and noticeable improvements in their ability to perform daily activities. Beyond simply alleviating pain, there have been instances where individuals described an improvement in their emotional well-being and overall quality of life following successful spinal cord stimulation. Stem cells may also repair and replicate damaged spinal nerves leading to cure.

In both scenarios, close collaboration between patients and healthcare providers is integral in determining whether these interventional treatments align with one's individual needs and preferences. It's important to thoroughly explore all viable options while considering potential benefits, risks, and long-term implications before embarking on such treatment paths.

By embracing a clear understanding of these interventional treatments such as injections and stimulation, individuals navigating chronic neuropathic pain can make informed decisions about how to best manage their condition.

Complementary Therapies: Acupuncture, Yoga, and Meditation

While medication and interventional treatments are crucial for managing neuropathic pain, integrating complementary therapies can offer additional benefits in the holistic management of chronic pain. Let's explore the potential benefits of acupuncture, yoga, and meditation as part of a comprehensive approach to pain management.


This ancient Chinese practice involves the insertion of thin needles at specific points on the body to stimulate natural pain-relieving chemicals like endorphins. By targeting these strategic points, acupuncture aims to restore the body's balance and alleviate discomfort. Despite its unconventional nature, numerous studies have highlighted its effectiveness in reducing neuropathic pain and improving overall quality of life.

In particular, a study published in JAMA Internal Medicine demonstrated that acupuncture was significantly more effective than sham acupuncture in reducing chronic pain. The precise and balanced nature of acupuncture speaks to its potential as an alternative or supplementary treatment option for individuals with neuropathic pain.


The gentle, deliberate movements and focused breathing techniques employed in yoga make it a valuable therapy for those seeking relief from chronic pain. Through its emphasis on mindful stretching and relaxation, yoga can help reduce pain intensity, enhance mood, and improve physical function.

Research published in the Journal of Pain Research emphasized the positive effects of yoga in reducing neuropathic pain and improving overall quality of life. The study highlighted the importance of yoga as a complementary therapeutic option due to its ability to address both physical discomfort and emotional well-being. Embracing yoga as part of a comprehensive pain management regimen can yield multifaceted benefits for individuals living with neuropathic pain.


Mindfulness meditation and deep-breathing exercises have garnered attention for their potential to alleviate chronic neuropathic pain. By fostering a state of mental tranquility and promoting heightened awareness of sensory perceptions, meditation techniques aim to reduce pain intensity and emotional distress associated with persistent discomfort.

A research study published in the Journal of the American Medical Association (JAMA) Neurology demonstrated the benefits of meditation in managing chronic neuropathic pain, showing improvements in pain intensity and psychological well-being. Additionally, a meta-analysis in the Journal of Pain and Symptom Management found that meditation was associated with reduced pain intensity and improved physical function in patients with neuropathic pain. These findings underscore the valuable role of meditation as a complementary approach to enhance overall well-being amid the challenges of living with neuropathic pain.

As we continue our exploration into effective management strategies for neuropathic pain, it's vital to understand the pivotal role that healthcare professionals play in guiding patients towards optimal treatment plans. Therefore, let's now turn our attention toward navigating the process of consulting a physician for neuropathic pain.

Consulting a Physician or Surgeon for Neuropathic Pain

Dealing with chronic pain can be a lonely and overwhelming journey. Sometimes, it feels like you're lost in a jungle without a map, not knowing which direction to take or whom to turn to for guidance. But believe me when I say this—having a compassionate and knowledgeable physician by your side can make all the difference.

When you have been experiencing persistent neuropathic pain, it's critical to reach out to a healthcare professional who has an understanding of how to help manage your specific needs. Head and Neck surgeons, Oral and Maxillofacial Surgeons are the appropriate specialties to diagnose and manage the pain once general physicians and neurologists have gone as far as they can. They can assess both your particular condition and medical history, enabling them to chart a personalized treatment plan that aligns with your individual requirements. Treatment may include all of the above including stem cells.

A thorough evaluation may involve discussions about your medical history, any accidents or surgeries you've had, and the medications or treatments you might have tried before. It could even include details about the environmental or lifestyle factors that might contribute to your pain experience.

This personal touch is incredibly important because each person's experience of chronic pain is unique. What works for one person might not necessarily work for another. Therefore, a tailor-made approach to treatment can significantly enhance its effectiveness.

Regular follow-ups and check-ins are also crucial as they allow your healthcare provider to monitor how you are responding to the treatment plan and make necessary adjustments if needed.

By collaborating closely with a healthcare professional specialized in managing neuropathic pain, you’re creating a solid foundation for effective treatment that acknowledges and addresses your unique pain experience.

As we carefully lay the groundwork for effective chronic pain management through personalized treatment plans and close collaboration with healthcare providers, we come to recognize the importance of holistic lifelong strategies for addressing neuropathic pain.

Neuropathic Pain: Management and Lifelong Strategies

Living with chronic neuropathic pain is an ongoing journey, often requiring a comprehensive approach to effective management. This typically involves not just one treatment, but a combination of different methods, lifestyle adjustments, and consistent monitoring.

Patients dealing with neuropathic pain may find relief from combining medications, physical therapy, psychological support, and emerging treatments such as stem cell therapy to comprehensively address their symptoms. Medications may include anticonvulsants, antidepressants, topical treatments, and in some cases, opioid therapy under careful supervision. It's important to approach medication regimens cautiously, always ensuring that potential benefits outweigh the risks.

Moreover, lifestyle adjustments including regular exercise routines tailored to individual capabilities and dietary modifications promoting anti-inflammatory foods can have significant positive impacts on pain management. Psychological support through cognitive-behavioral therapy (CBT) or support groups can also contribute to improved coping strategies and emotional resilience.

Regular follow-ups with healthcare providers are crucial to assess the effectiveness of ongoing treatments and make necessary adjustments to the care plan. This helps ensure that any emerging issues, changes in symptoms, or side effects from treatments are promptly addressed.

In addition, engaging in alternative therapies like acupuncture, yoga, and mindfulness meditation has shown promise in alleviating neuropathic pain for some individuals. These alternatives can complement traditional medical treatments, providing further support in addressing discomfort and enhancing overall well-being.

While no single approach works universally for everyone dealing with neuropathic pain, customization of treatment plans based on the individual’s response to various therapies is key to effective long-term management. Therefore, continued vigilance and flexibility in adjusting treatment strategies are indispensable components of mitigating the impact of chronic neuropathic pain.

The multifaceted landscape of managing chronic neuropathic pain underscores the necessity for an individualized and holistic approach—a framework that recognizes personalized care and the dynamic nature of symptom management.

For more information about personalized neuropathic pain management strategies and potential stem cell treatment options, feel free to request a consultation.

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