Dementia


Pathology: 

Dementia is a condition characterised by progressive or persistent loss of intellectual functioning, especially with impairment of memory and abstract thinking, often with a personality change, resulting from organic disease of the brain. Commonest form of dementia is Alzheimers disease. The aetiology of the disease includes primarily vascular insufficiency, amyloidosis and neuronal degeneration from genetic influences. Environmental influences would include brain trauma from boxing or football and atherosclerotic micro-vessel angiopathy from smoking.

Symptoms of dementia include cognitive and psychological changes:

  • Memory loss
  • Difficulty communicating
  • Visual and spatial disorientation
  • Difficulty reasoning or problem solving
  • Confusion
  • Personality change
  • Depression
  • Paranoia
  • Agitation 

Since the impact of dementia is so profound and spread across so many societal groups it is important to view these groups opinions on stem cells. The Alzheimers Society of the UK state:

’Stem cells can grow into brain cells and as a result may have the potential to repair brain damage caused by neurological conditions such as dementia. Although stem cells act in similar ways there are types of stem cells which are present in the body throughout adult life; embryonic stem cells, induced pluripotent potent stem cells which can be created in the lab from ordinary adult cells and have ‘reverted’ back into a stem cell. Alzheimers Society mainly fund research that use adult stem cells and induced pluripotent stem cells that do not raise ethical concerns. 

It is noted that eurostemcell.life only use autogenous cells (your own) from the patients mesenchymal fat and do not use fetal, allogeneic nor embryonic stem cells.

STEM CELLS USED FOR DEMENTIA

By their very nature stem cells are the building blocks of our body, incorporating the foundation and the cladding. They are also the wiring, plumbing, roof and fence. Our genes and DNA are intrinsically entwined with our cells and regulate and modulate the systems in our body. As we age our physical production of cells is rate and age limited; however up to the day of our death we still have the capacity for our remaining stem cells to differentiate into the cells controlling our organs and systems. It could be described that our piggy bank of cells gets smaller cause for years and years we are removing stem cells and not replenishing. That is the very nature of why stem cell infusions are important, because discovery of these important cells enables us to grow and expand them exponentially to assist the body via a ‘top up’. It is exactly the same when a surgeon does a bone graft; they are utilising the small number of stem cells in the graft to grow and replenish a bone defect. The bone itself acts as a scaffold, the stem cells encourage the growth of blood vessels and subsequent incorporation of the graft.

SUMMARY

Eurostemcell.life advocate that Stem Cell infusions via autogenous fat harvesting to procure Mesenchymal Stem Cells is suitable for an anti-dementia strategy although no clinical results are available to verify its efficacy. Indeed our own suggestion is that stem cell infusions should start from the 4th or 5th decade to keep up with the rate limiting decreased production of stem cells as we get older. Nevertheless we would harvest the stem cells from elderly patients only if minor surgery is medically safe. We would advocate a stem cell infusion twice in 1 week and with supplemental HBOT (Hyperbaric oxygen therapy increases stem cell differentiation) if no medical contra indication.

The diagnosis of dementia can be a life changing event for the patient and family. There are no easy medical cures. The use of stem cells and hyperbaric therapy is a relatively low risk procedure that may or may not have results. Ideally for dementia the earlier the stem cell treatment and HBOT the better, multiple treatments may be required. Professor Vickers and his team are ready to assist.

At Eurostemcell.life we pride ourselves on ensuring patients know the team diagnosing and conducting their stem cell therapy. Professor Russell Vickers is the lead specialist, working within a team of specialist surgeons and doctors.

Important questions that patients should ask of any treating clinicians and facility:

  • Are my treating doctors specialist surgeons/doctors and stem cell experts?
  • How many publications and research based studies have they published in peer reviewed journals?
  • Can they augment stem cell therapy with the known benefits of adjunctive therapy?

Eurostemcell.life is Europes premier stem cell organisation guided by evidence based medicine and clinical research.

Our founding director, Professor Russell Vickers PhD, MDsc, M Med, MA, FFPM (ANZCA) is an Australian and New Zealand board registered surgeon with over 100 publications, books and thousands of invited lectures and presentations on stem cells, pain, peptide synthesis and biochemistry. Professor Vickers is the leader of a family team of surgeons assisting him including Dr Peter Vickers, MD, FRCS (Edinburgh), FRACDS, Dr Richard Vickers, MD, FRCS (England, Glasgow, Ireland), FRACDS (OMS) and Dr Jessica Vickers, MD, MCOM, BA/BN as co-ordinator.

This medical summary has been written by Professor Vickers and his family team of specialist consultants.

It has been written by medically qualified writers.

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