Headache and Migraine


A headache is any pain in the head, behind the eyes and above the ears. It may be described as throbbing, constant, sharp or dull.

Migraines are recurring headaches which could be described as disabling and affecting the quality of life. It is thought that migraines may be associated with vascular or nervous disorders. A migraine attack may last up to 72 hours and cause nausea and vomiting, photophobia and hearing sensitivity.

Migraines themselves are quite common with 15% of the population affected. It is thought that some predisposing factors may include hormonal, dietary, emotional or physical factors.


It has been reported in the literature that stem cells are anti-inflammatory and that the possible process for treatment success is that the stem cells target neurogenic inflammation which is a well documented reason for migraine pathogenesis.

Some traditional treatments such as analgesics and Botox may be ineffective over the passage of time. Professor Russell Vickers has published an article in 2014 where stem cells were used to treat neuropathic pain which has a similar degree of pain threshold to migraines.

Vickers ER, Karsten E, Flood J, et al. A preliminary report on stem cell therapy for neuropathic pain in humans. J Pain Res. 2014;7:255–263. [PMC free article] [PubMed] [Google Scholar]

It is theorised by Professor Vickers that stem cells reduce inflammation in the arterioles and venous channels in the meninges and dura surrounding the brain.

The stem cells also have a direct effect on the neurons if there is associated inflammation.

Obviously the patients treating physician should rule out other organic causes of headache and migraine by physical examination and MRI to exclude a brain tumour. 

Where everything is normal, the treatment of symptoms is paramount.


The diagnosis and treatment of headache and migraine can be challenging. Indeed most physicians will also want to rule out a brain tumour. Conventional therapy with analgesics and botox may only be a temporary solution.

In respect of the use of adult mesenchymal stem cells it is acknowledged that many physicians see this therapy as being used once everything else has failed. As such the patient should be aware that there may be limits as to the effectiveness of stem cells. For moderate to severe symptoms one would expect good results with individual variations. There are very few, if any, double blind controlled trials on the use of stem cells in headache and migraine.  

The use of stem cells should be reserved for those patients whose conventional therapy has failed. Prior to consideration of stem cells you would need to undergo the treatment of mini liposuction and IV stem cell injection and/or infusion.

At Eurostemcell.life we pride ourselves on ensuring patients know the team diagnosing and conducting their stem cell therapy. Professor Russell Vickers is the lead specialist, working within a team of specialist surgeons and doctors.

Important questions that patients should ask of any treating clinicians and facility:

  • Are my treating doctors specialist surgeons/doctors and stem cell experts?
  • How many publications and research based studies have they published in peer reviewed journals?
  • Can they augment stem cell therapy with the known benefits of adjunctive therapy?

Eurostemcell.life is Europes premier stem cell organisation guided by evidence based medicine and clinical research.

Our founding director, Professor Russell Vickers PhD, MDsc, M Med, MA, FFPM (ANZCA) is an Australian and New Zealand board registered surgeon with over 100 publications, books and thousands of invited lectures and presentations on stem cells, pain, peptide synthesis and biochemistry. Professor Vickers is the leader of a family team of surgeons assisting him including Dr Peter Vickers, MD, FRCS (Edinburgh), FRACDS, Dr Richard Vickers, MD, FRCS (England, Glasgow, Ireland), FRACDS (OMS) and Dr Jessica Vickers, MD, MCOM, BA/BN as co-ordinator.

This medical summary has been written by Professor Vickers and his family team of specialist consultants.

It has been written by medically qualified writers.

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